Anavex Life Sciences Corp (AVXL)

[XenaLives]

I find this paragraph in the article to be odd:

At the risk of oversimplifying, Alzheimer’s disease likely begins with an infectious agent or head trauma. (The rare inherited forms, which strike people in their 50s, are caused by mutations.) In response, the brain ramps up production of amyloid, which forms sticky plaques between neurons. That triggers inflammation as well as production of the “other” Alzheimer’s protein, called tau, which accumulates within neurons; both inflammation and tau are toxic to neurons.

The author omits environmental toxins which are almost certainly a factor. Alzheimer's is found with increased frequency around urban interstate highways for example.

A quick google of this phrase "environmental toxins epigenetics Alzheimer's" shows this is an important area of study.

Environmental chemical exposures and human epigenetics - NCBI - NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304523/
by L Hou - ?2012 - ?Cited by 323 - ?Related articlesDec 13, 2011 - After 48 or 96 h of exposure to the chemical, they observed hypermethylation of Rnd2 gene in Hg-treated mouse embryonic stem cells. Lead is among the most prevalent toxic environmental metals, and has substantial oxidative properties. Long-term exposure to lead was shown to alter epigenetic marks.
?Abstract · ?Background · ?Epigenetic factors · ?Environmental pollutants ...

Alzheimer's Disease and Environmental Exposure to Lead: The ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567843/
by KM Bakulski - ?2012 - ?Cited by 103 - ?Related articlesAlzheimer's Disease and Environmental Exposure to Lead: The Epidemiologic ... Recent research suggests the importance of epigenetic mechanisms in defining the .... A small percentage of circulating Pb is highly toxic because it is free and ...

Epigenetic Alterations in Alzheimer's Disease - NCBI - NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681781/
by JV Sanchez-Mut - ?2015 - ?Cited by 76 - ?Related articlesDec 17, 2015 - Keywords: Alzheimer's disease, epigenetics, neuroepigenetics, DNA ... nutrition (Cooney et al., 2002), and environmental toxins (Anway et al., ...

Frontiers | The Epigenetics of Alzheimer's Disease: Factors and ...
https://www.frontiersin.org/articles/404609
by X Liu - ?2018 - ?Cited by 1 - ?Related articlesNov 30, 2018 - The pathology of LOAD is multi-factorial with biological, genetic and environmental ... The diagram shows different factors of epigenetics in Alzheimer's ..... from oxidative stress and amyloid ß-protein toxicity (Rougeulle et al., ...

Epigenetic Modification and Its Role in Alzheimer's Disease - FullText ...
https://www.karger.com/Article/Fulltext/437329
by YP Zhu - ?2015 - ?Cited by 3 - ?Related articlesSep 12, 2015 - AD is a complex disease and encompasses many prominent risk factors, such as aging and genetic, environmental, and vascular factors. So far, its pathogenesis has not been clearly elucidated. Mutations in specific genes have been identified; however, they can only explain 5-10% of the AD cases.

Pesticides Raise Risk of ALS and Potentially Alzheimer's Disease ...
https://www.alzforum.org/.../pesticides-raise-risk-als-and-potentially-alzheimers-diseas...
May 21, 2016 - Most scientists believe that genes and environment each contribute to the onset of ... had long-lasting epigenetic changes (see Wu et al., 2008; Bakulski et al., 2012; .... Does DDT's Toxic Legacy Include Alzheimer's Disease?

Epigenetic Diet May Prevent Alzheimer's Disease - Pharmacy Times
https://www.pharmacytimes.com/.../epigenetic-diet-may-prevent-alzheimers-disease
Oct 9, 2014 - With no available cure for Alzheimer's disease (AD)—and none on the ... to environmental factors such as diet and toxins throughout their lives.

Epigenetic and Neurological Impairments Associated with Early Life ...
https://www.hindawi.com/journals/ijg/2019/2085496/
by N Grova - ?2019 - ?Related articlesOct 31, 2018 - The role of those environmental factors which may affect epigenetic DNA ..... and the more toxic Aß1-42 at 90% and 10% abundance, respectively [89]. ... between pollution exposure and cognitive decline and dementia, ...
Organophosphates Induced Alzheimer's Disease: An Epigenetic Aspect
clinical-epigenetics.imedpub.com/organophosphates-induced-alzheimers-disease-an-e...
The exposure may also occur through the consumption of contaminated food products and environmental toxicity. Recent studies suggested that exposure to ...