NorthWest Biotherapeutics Inc (NWBO)

[CogDiss 1188X]

Great find, Evaluate!

One of the references in the GBM study was for neoantigen-specific T-cell detection in an ovarian cancer patient using whole tumor lysate vaccine, without the additional neoantigen peptide priming used in the GBM study:

Vaccination induced T cell responses to autologous tumor antigen, which were associated with significantly prolonged survival. Vaccination also amplified T cell responses against mutated neoepitopes derived from nonsynonymous somatic tumor mutations, and this included priming of T cells against previously unrecognized neoepitopes, as well as novel T cell clones of markedly higher avidity against previously recognized neoepitopes. We conclude that the use of oxidized whole-tumor lysate DC vaccine is safe and effective in eliciting a broad antitumor immunity, including private neoantigens, and warrants further clinical testing.

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