Marizyme, Inc. (MRZM)

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Marizyme currently has 4 product candidates derived from the protease enzyme platform acquired from ACB Holding AB. The first product candidate is MB101 which is targeted to be used to debride and heal human wounds. MB101 is a clinical stage candidate which was tested in 13 human clinical stage studies conducted by ACB Holding AB prior to this drug candidate’s acquisition by us. In these studies, which were designed as Phase II efficacy studies and conducted in Sweden, Germany, Finland, Switzerland, United Kingdom and the Netherlands, more than 500 patients were treated for wound debriding and healing. No clinical trials of MB101 have been conducted in the United States. The second product candidate is MB102 which is targeted for acute cerebral ischemic stroke in pediatric patients. It is derived from the same protease enzymes that MB101 is comprised of. MB102 is in preclinical stage of development. In June 2018, prior to our consummation of the asset acquisition, ACB Holding AB filed a Pre-IND for MB102 and received an FDA letter giving advice towards an Investigative Drug Application for MB102, which we expect to file in late 2019. MB103 is Marizyme’s third product candidate and is in preclinical development. It is derived from the same protease enzymes as MB101 and is targeted to treat acute myocardial infarction, or AMI, in human adults. The fourth and last product candidate is MB104 which is targeted to treat deep vein thrombosis. It is in early preclinical development and is derived from the same protease enzymes as MB101.$MRZM