NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

Two things to note. 1) FDA was really fooled by the early PFS responders doing poorer than the control thus PFS faked out FDA to initiate the hold in 2015, imo. Those two charts PFS and OS that Carlo gave make perfect sense. And the late PFS line performs way better than the control was the waiting time bet 2015 and 2017 for FDA to see and lift the Hold. And so is now LP says there was a hostile takeover and much more that they struggled to sustain and on. 2) AF says lysing the tumor that has neoantigens and pulse it with DC won't wok but needs a special T cell engineering - what the heck is he talking about. Bigger et al are laughing at him. Where did Carlo get the PFS chart?

Marzan,

Those two charts PFS and OS that Carlo gave are not from the Dcvax-L trial but from a Phase II Clinical Trial using whole Cell Lysate Dendritic Cells Vaccine for Glioblastoma.

World Neurosurgery
Volume 77, Issues 5–6, May–June 2012, Pages 736-744
Article:

"Adjuvant Immunotherapy with Whole-Cell Lysate Dendritic Cells Vaccine for Glioblastoma Multiforme: A Phase II Clinical Trial."
https://www.sciencedirect.com/science/article/pii/S187887501101000X?via%3Dihub