Amarin Corp Plc (AMRN)

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Thanks AVII for the helpful input on Odyssey and the audio!

Question:

In the Primary Report of Odyssey, based on pre-specified sequential ( hierarchical) analyses, CV mortality showed no independent benefit and Total Mortality below revealed a “nominal” p value = 0.026 which essentially implied hypothesis generating.

In the more recent Total events report of Odyssey, the authors mention the original publication of total mortality and indicate that this “observation “ of decrease in total mortality was again “supported”.

Is this a clever play of words or statistical gymnastics?

The Abstract of this paper includes decrease in total mortality and the audio you kindly shared with us also mentions the same statement.

Two of my cardiologist friends last week shared with me that the Pharma Reps are telling them that that Odyssey did show a mortality benefit!

Is this a valid scientific take from a pre- specified analysis which I interpret as exploratory or hypothesis generating?

Two hypothesis generating statements do not add up to a hypothesis testing conclusion! Do they ???

Would appreciate your input AVII !