NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

It makes sense. The antibodies (CIs) help restart the immune response, and with the tumor still in, more antigen uptake is possible for the encroaching calvary of antigen expressing cells. If you introduce CIs by themselves after surgery, they have less chance for broad antigen uptake and more chance for interference from the inevitable chemoradiation. It is the first impact that I recall Dr. Allison's colleagues determined was the most important. If you dilute the first immune response, I think the theory is you are almost telling the body to partially tolerate the cancer....and that just won't do.