NorthWest Biotherapeutics Inc (NWBO)

[alphapuppy]

I suspect that you are correct, and I would bet that the reason there were so many early censors in the Optune trial, was because of patient intolerance to the device.

Remember, these patients have to put this thing on their head for 18 plus hours a day essentially seven days a week. Some people, a lot of these people, just cannot tolerate doing that.

So a higher number of these patients were censored out early. Or they hated putting on the device so much that they ended up going on different treatments which cause them to censor out.

So yes I agree with you that the remaining patients that are highly motivated to continue with the optune device, are the patients that form the bulk of the remaining KM curve. So hence these are likely patients,because of their highly motivated status, which may actually translate into them having better progression free survival compared to those who censored out early.

It is a significant potential bias that may not be totally recognized by the data And by the overall KM survival curves.