NorthWest Biotherapeutics Inc (NWBO)

[jammyjames]

Hi cog. Sorry i was on holiday so hadn´t got round to responding. Good effort trying to dig up some evidence.

Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma.

Unfortunately there appears to be no negative control in this study so i´d take the results with a pinch of salt (they internally controlled with the same patients pre and post vaccination). By that i mean they didn´t test whether there´s an expansion of CTLs that are specific to non-tumour associated antigens. i.e it might be a general rather than specific effect - for all we know there's an expansion of CTLs targeting Actin!

Monitoring of Regulatory T Cell Frequencies and Expression of CTLA-4 on T Cells, before and after DC Vaccination, Can Predict Survival in GBM Patients

Cytokine responsiveness of CD8+ T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients

These two papers do not address neoantigens.

Overall as i mentioned before this has no bearing on whether DCVax-L works or not, simply I still haven't seen any strong evidence that the DCVax-L MOA (assuming it has some action) is by directing the immune system to neoantigens.