Wednesday, January 23, 2019 5:35:30 PM
Wrong. If everybody was randomized exactly 3.6 months post surgery there would absolutely zero effect on the P value based on the earlier start.
The only very minor effect is that some events could be reordered as not everybody had the exact same time from surgery. And this effect would be small and could go either way.
The idea of measuring from surgery is nonsense. The patients enrolled in the -L trial had no events prior to randomization. And you want to compare that to trials that did have events in those months.
Why not simply run a trial that randomizes at 3 years post surgery. What will the median OS be on that as measured from surgery?
How about a trial of brain damage due to a gunshot to the head? I will randomize those who survive 1 week. I bet they do a hell of a lot better than those diver sees, even adjusting by a week. (no offense meant to diver).
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