NorthWest Biotherapeutics Inc (NWBO)

[CogDiss 1188X]

Neoantigen vaccine generates intratumoral T-cell response in Phase 1b glioblastoma trial

https://www.nature.com/articles/s41586-018-0792-9

Patients who did not receive dexamethasone—a highly potent corticosteroid that is frequently prescribed to treat cerebral oedema in patients with glioblastoma—generated circulating polyfunctional neoantigen-specific CD4+ and CD8+ T cell responses that were enriched in a memory phenotype and showed an increase in the number of tumour-infiltrating T cells.

Presumably whole tumor lysate should work better but interesting nonetheless.

Let’s see if jondoeuk is awake this morning