NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

flipper44,

They also inject Direct near the margins to be sure to stay close to the known lymph zones for the migrating and, therefore, mature DCs. Necrosis occurs in the tumor in the first place as it grows because the tumor itself is oxygen starved and in constant need of new vasculature to support it as it expands. Cancer spends it's energy on expansion and not on self preservation. NWBO understands this very well. Some of the most conserved antigens survive in areas close to this most hypoxic (low oxygen) environment which makes them difficult to access by the immune system. If I recall correctly, neoantigens are generally located closer to the outer edges of the tumor and in mesenchymal subtype especially are often related to motility, metastasis and exozomes. DC therapies have shown promise in their ability to locate and present these important neoantigens. Injecting near the margins helps the vaccine do this job better. Best wishes.