Hi Flyingj,
Immunology, let's say, in a broad term, is making ones own body fight/cure a disease.
In that sense, there is all kinds of immunology.
We talk about MRKR's multiTAA T cell.
And CAR T cell (chimeric antigen receptors T cell)
And ACT (adoptive cell transfer)
There's more quasi "immunology"
RNAi (RNA interference)
mRNA (messenger RNA)
CRISPR (clustered regularly interspaced short palindromic repeats)
Kinase inhibitors
TIL's (Tumor infiltrating lymphocytes)
PDL (Programmed death ligand)
and etc.
All are trying to produce a response so your body heals itself.
At this point, I don't think anybody or any company knows for sure what will or will not work "most of the time".
What we do know is this, some of the therapies on the above list HAVE worked … and some of those same therapies have Killed their patients.
To twist a saying, MRKR is trying to KISS (keep it simple ------).
I don't think the human body really likes all this genetic manipulation/interference.
Look at all the crazy side effects of every medicine commercial on TV.
A lot of times they are worse than what they are trying to cure.
I once took Zyban, it almost killed me (severely allergic to it).
Take this to cure a headache, but it might give you liver disease.
Take this to stop itchy skin, but it might give you kidney failure.
MRKR is trying to "keep it simple", with NO incidence of cytokine release syndrome, neurotoxicity or any other serious adverse events related to the therapy.
CAR-T has had problems.
CRISPR has had problems.
RNAi has had problems.
I've owned all those technologies in the past (and made $).
MRKR's two giant pluses are NO cytokine release syndrome, AND
significant evidence of epitope spreading with expansion of endogenous T cells specific for tumor-associated antigens that were NOT targeted by the MultiTAA product.
Your body creating "additional" antigens that can help cure you "for free", because they were not even targeted to be produced (with no nasty side effects), I think is HUGE.
Right now, I'm betting on MRKR curing and not killing.
