Statins reduce LDL by 50% or more, there is a study that shows 79% of people that went off statins saw the LDL go from under 100 to over 100 vs 3% of the statin group(yes 3% of statin group went from 60’s to over 100) in a group with LDL in the 60s at start of trial but started on average before statins at 130’s. This was only a 10 week trial.
Since studies show statins have little or no effect for people starting under 100 I assume most in RI were above 100 before statins, if so if statins were blocked then 79 % of them in RI should have gone above 100 and significantly so, you can’t have overwhelming proof statins drop LDL 50% or more and then say statins were blocked with a small rise when reverting to the mean is a perfectly logical explanation.
If someone is really saying that statins were not working and all that happened was the small increase then all the studies on statins that show it’s large effect on LDL apparently are now fraudulent?
I have not even gotten to the fact that there is zero evidence LDL under 100 leads to heart events.
In addition to that non-statin fact Statins have shown to not work in people starting under 100 LDL. Yes understand people did not start below 100 before statins but there are no studies that indicate small changes in ldl under 100 are harmful.
Statins were obviously working:
1: LDL did not increase as they should based on people stopping statins having large LDL increases
2. Statin side effects were still happening
3. A large number did NOT have LDL increase, almost impossible if statins were not working
4. Even people on statins can have LDL go from 60 to over 100 in 10 weeks so small overall movement not that meaningful
5. The fact the effects were mostly early on and then moderated or were less over time highly correlated with reversion to the mean rather than statins not working, why would things not get worse the longer statins blocked, especially when they were not effected by any large percentage to begin with, makes no sense
If statins main benefit is this small on LDL difference in 6 years.....I don’t even have a finish to that sentence because it is such an absurd thought...If statins were not working things would have recorded much much worse.
