Friday, November 23, 2018 12:12:15 PM
SNO is an amazing meeting. Aside from all of the presentations, I got to meet and talk with many brain tumor researchers and physicians and discuss what they think are the best treatments, what is needed to advance the field, what is slowing down progress and much more.
We also were able to interact with many other brain tumor nonprofits. There was some resistance in the past to working together but I think the last barriers were recently removed and you are going to see a lot more collaboration now. We are all about collaboration. Working together we will be able to accomplish much more than any of us could individually.
The Society for Neuro-Oncology held their annual meeting last week in New Orleans. This was completely overwhelming. There were 100s of sessions and over 900 posters. Everyone I talked to had different favorites but these are the topics that stood out to me:
• Onc-201 for H3 K27M gliomas (which includes brainstem gliomas, DIPG, Midline GBMs, Spinal GBMS, Thalmic Tumors, usually on younger people). Early data in small group of patients at least doubled expected survival time with many patients still alive. This is a simple oral drug with minimal side effects.
*
* PVS-RIPO (Polio Virus Vaccine) – many presentations showing promise. One pre-clinical poster in particular showed that the target of the Vaccine is over expressed in most Medulloblastoma and ATRT tumors – which supports their new clinical trial using it on these tumor types in addition to the GBMs.
*
* DC-Vax-L: They still did not unblind the data from their phase 3 trial which ended 3 years ago, but presented more follow-up on the unblended data they reported on 6 months ago. Looks interesting but we can’t tell until they present the unblended data. They did say they will unblind the data soon.
*
* ABT-414: This is for recurrent GBM that overexpress EGFR. They showed some promising data – ABT-414 plus Temozolomide compared to Temozolomide and CCNU increased the overall survival at 2 years from 5.2% to 19.8%.
*
* SRS (Stereotactic radiosurgery) + Avastin for recurrent GBM did better than chemo plus Avastin, progression free survival of 5.3 months vs. 1.3 months. SRS is a form of radiation, and adding it at the time of recurrence is relative easy and adds a big benefit. It can be done after the “maximum lifetime“ dose of radiation. It is worth considering.
*
* SurVaxM (Survivin Vaccine). Survivin is a protein that is overexpressed on almost all GBMs. Early results look promising: Minimal side effects and for newly diagnosed GBM, survival at 1 year of over 94%.
*
There were 2 negative trials that were unexpected:
* VB-111 + Avastin for recurrent GBM did not do any better than Avastin alone.
*
* Ribociclib for recurrent GBM did not improve progression free survival and was found to not cross the blood brain barrier.
Disclosure: The Musella Foundation has funded some of the development of Onc-201, DC-Vax and PVS-RIPO.
https://virtualtrials.com/news3.cfm?item=6575
Recent NWBO News
- Biophma Announces Exclusive In License for Dendritic Cell Technology, Sending Shares Higher • AllPennyStocks.com • 06/17/2024 04:40:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/04/2024 09:11:16 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 06/03/2024 09:22:55 PM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 05/22/2024 08:13:36 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/10/2024 09:04:57 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 03/01/2024 10:04:38 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 12/02/2023 01:31:35 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/16/2023 10:11:54 PM
- Epazz, Inc. (OTC Pink: EPAZ) ZenaDrone Demonstration to Defense Departments of UAE and Saudi Arabia • InvestorsHub NewsWire • 11/15/2023 12:19:31 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/09/2023 09:30:39 PM
- Epazz, Inc. (OTC Pink: EPAZ) US Navy Collaboration ZenaDrone 1000 • InvestorsHub NewsWire • 11/09/2023 01:00:34 PM
- Epazz, Inc. (OTC Pink: EPAZ) US Navy Collaboration ZenaDrone 1000 Extreme Weather Demo • InvestorsHub NewsWire • 11/07/2023 12:29:43 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/09/2023 08:36:14 PM
Last Shot Hydration Drink Announced as Official Sponsor of Red River Athletic Conference • EQLB • Jun 20, 2024 2:38 PM
ATWEC Announces Major Acquisition and Lays Out Strategic Growth Plans • ATWT • Jun 20, 2024 7:09 AM
North Bay Resources Announces Composite Assays of 0.53 and 0.44 Troy Ounces per Ton Gold in Trenches B + C at Fran Gold, British Columbia • NBRI • Jun 18, 2024 9:18 AM
VAYK Assembling New Management Team for $64 Billion Domestic Market • VAYK • Jun 18, 2024 9:00 AM
Fifty 1 Labs, Inc Announces Acquisition of Drago Knives, LLC • CAFI • Jun 18, 2024 8:45 AM
Hydromer Announces Attainment of ISO 13485 Certification • HYDI • Jun 17, 2024 9:22 AM