Amarin Corp Plc (AMRN)

[bogatie]

Congrats on your short; I think you should cover it sooner than later.

I'd like to respond to the FUD you posted by citing the TNT Trial. In that trial, LDL-C in the 80mg statin group was at median 77mg/dL at year 4.9 years. The 10 mg statin group was at 101mg/dL. That is a 29% difference (not a 9% difference as was seen in REDUCE-IT 77 vs 84 mg/dL LDL-C.) As important, was that the 80mg statin side was in the sweet spot of LDL-C 70s-80smg/dL, as opposed to the 10 mg statin group which was above 100mg/dL.

So you take a trial with a 29% difference in LDL-C bewteen its arms and use it as evidence for why a trial that sees a 9% difference in LDL-C (although that difference made no outcome difference across the placebo group, regardless of whether LDL-C went up or down) and then conflate the result to state REDUCE-IT would have failed if not for the mineral oil.

Nice job at some sophisticated lying.

I personally think that mineral oil made no difference in the outcomes, but even in a worst-case scenario, perhaps a 2-4% difference in outcomes - not 25%. (As Amarin has stated)