Amarin Corp Plc (AMRN)

[jessellivermore]

Review for the day...

DPA...Sorry Jomama...There is no convincing evidence that DPA is going to run EPA off the road..The DPA story is like the Krill story. Because it's more exotic it's got to be better...

Problem #1..Most fish oils contain less than 2% DPA by weight, roughly one-third to one-fifth of the EPA or DHA content. DPA is also to a great deal convertible to EPA and vice versa...DPA could be more effective on per gm dosage than EPA is in lowering trigs...DHA is more effective than EPA in lowering Trigs..The DPA people trigs are basing their argument on the trig lowering aspect...It's an eight year job to find out whether or not DPA can match EPA for CVD event risk...And the DPA guys are short on money...I don't know what your intent is coming on this board to hype DPA...But you sound like a salesman...Your arguments don't hold water and you are talking to very well informed customers...

Statins and CVD risk...It may come as a shock to some of you, but the case for statins and LDL-C is not as tight as you might as you imagine...There was a time before 1960 when high cholesterol was over 300 mg...Then came the statin revolution..The idea was just too damn good not to be true...Cholesterol streaking of the Aorta in young fatalities of the Korean war implicated cholesterol..particularly LDL-C.
as the most likely villain...And statins..drugs that lowered the hepatic synthesis of cholesterol were hailed as the new wonder drugs..And steadily the definition of high cholesterol began to fall, and. fall till now we a calling LDL-C over 75mg/dl...a cardiac risk..

There were always holes in the story and if this was physics or math statins would have went out with "Shaboom"...First time MIs were more likely in patients with low LDL-Cs... Though the C levels were getting lower and lower the cardiac events were not going away...

There was a huge problem because statins were so profitable. Up until 2007-2008 when when congress passed the "Clinical Trials Reform Act" all the trials were being run by BPs with little oversight. For example Crestor actually failed three outcomes trials before getting a positive in JUPITER....JUPITER stands alone (as far as I can determine) as the only primary intervention CVOT using statins that showed stat positive results..

We do hear that statins have anti inflammatory properties and JUPITER apparently "proved" (an AZN trial..We know how honest AZN is) the Hs-CRP said so even though the principal investigator held the patent on the Hs-CRP lab test...and stood to profit $14 mil if the test proved worthy...

Its too bad that all that money could be used to silence the critics of the statin LDL-C hypothesis...But I do not recall any truly comprehensive or compelling explanation on how statins..lower systemic inflammation..Not the case in EPA where we have volumes on every detail about how EPA works....

":>) JL