The Enzyme Factor
I cannot elaborate on the involved specific chemistries or physiologies of the various chemical entities described in the reading. Beyond my knowledge or comprehension; won’t venture into an area for which I have insufficient knowledge.
Nonetheless, I do note the involvement or reference to a number of enzymes, or their pathogenic products. Once again, two questions. What is the direct, frank, observed pathology; or much more importantly, what is the root, primal cause of the pathology. The reading refers to a number of chemical abnormalities strongly associated with Alzheimer’s (at various disease stages). These abnormalities can occur for (primarily) the following reasons.
Bad genetics. A mutation, a disrupted nucleotide sequence in a chromosome, causes wrong chemicals (proteins, usually in the form of enzymes) to be formed. Normal neuron chemistry does not then occur; a disease condition is created.
Good genetics, but abnormal enzyme synthesis. In this case, genes are normal, properly instructing the neuron to synthesize functioning enzymes. Enzymes simply control virtually all cellular chemical reactions in the cell. If they are properly (normally) formed, proper, healthful chemical reactions occur. All is well. But if the enzymes are not properly synthesized, if, for example, they are not properly folded into their precise configurations, pathology results downstream. In the case of Anavex 2-73, it restores proper function to the rough endoplasmic reticula, the organelles that synthesize enzymes. Cause the rough ER to properly fold enzyme proteins, all is well. If they are mis-folded, reactions fail, or (as in the case of the several molecules in the article) reactions or processes downstream are compromised; pathologically.
Lastly, but not in this case, metals or other enzyme toxins can disrupt enzyme production or function.
Once again, unlike any other known (to me, at least) potential Alzheimer’s therapy or drug, Anavex 2-73 corrects things at the upstream base; allowing the cell to once again synthesize normal enzymes. It fixes the root-cause; mis-folded enzyme proteins in the rough endoplasmic reticula.
My reading of the referenced information indicates a focus on various downstream outcomes. The upstream root causes are not addressed. Again, Anavex 2-73 is different — and so much better — in that regard
