NorthWest Biotherapeutics Inc (NWBO)

[Umibe5690]

Yes, indeed, and I calculate conservatively that overall Tx mOS is at least 28 months. If SOC is 20 months, then the delta, overall, should be in the 8 month range. While a primary endpoint, mPFS would not matter as much since it is used as a surrogate. Even if eventing were occurring earlier than expected, the delta between that and OS would be important. Additionally, earlier eventing could be followed by a decreasing rate and perhaps decline to zero as the long term effect of the vaccine took hold. Of course, success or failure is highly dependent upon the placement of control/SOC placeholder. JMHO, but I think 20 months is rather aggressive.