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Re: dia76ca post# 168041

Tuesday, 10/09/2018 4:16:11 AM

Tuesday, October 09, 2018 4:16:11 AM

Post# of 462217
dia76ca.Thank you for the response.

http://wsw.com/webcast/cantor7/avxl/

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He is difficult to follow in such a setting(rushed and w/o slides for us). His emphasis and selection of certain points is an important indicator of what he is thinking. Each listener might get a different emphasis through no one's fault (time compression, listeners background/knowledge, Dr.M.'s emphasis-time, what one selectively wants to hear) many factors. Seems that you and I both heard the same emphasis on this IND point. Knowing EXACTLY which patients will respond is of course a critical point for tieing to the FDA PM initiative moving forward. I can imagine how important it must be for people conducting trials to establish some basic control instead of the old days of," try it and we will see what happens". Which would be my own assessment of how AD trials have been done till now. This 80% of the population information alone will/should impress the room at CTAD as compared to any past shotgun trial information. I think we all understand that this represents only just the beginning of a learning process which will continue for many years. His emphasis on the use of the "human Body as a weapon" (my emphasis) seemed legitimately enthusiastic and a great message for everyone to consider.

I do expect HH to emphasize this point as he describes results at CTAD. There is still the concern about how much time he has (15 mins). The CTAD audience will however be better equipped as informed skilled science listeners. Doubts remain how HH will be able to present the many critical points AVXL must have. We'll see I guess.
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