RespireRx Pharmaceuticals Inc (RSPI)

[K-G]

wahjjhugo,
I am certainly not qualified answer your question, but I, too, find the description of the observed cellular changes very interesting.
First, during the CC, Dr. Stoll selected his words carefully, and seemed to go out of his way to emphasize that the observed response was toxicological in nature. However, he also pointed out that while the observed impact scaled with dosage, all effects disappeared after a short period of time (2 weeks?). To cellular biologists there may be some implications here that I cannot appreciate, but there are some basic questions that I don't think have been answered - do the affected cells die off but no other cells are affected once CX-717 is discontinued, or is there some cellular change that has been induced that resolves with the discontinuation of CX-717, leaving an apparently healthy cell? The fact the cellular response has never before been observed (tox or recovery?) is also quite interesting, and I'm sure the Cortex researchers are running in overdrive trying to understand what is occurring. Never-before-observed phenomena always have the potential to cause increases in understanding -one way or another.
I don't think these details have been discussed in this forum, but the description caught the attention of several posters who pointed out that the response may not be related to CX-717 (species specific metabolite, impurity, etc.) Perhaps one or more of the regular posters could help enlighten us.