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Re: CkFacts post# 166854

Wednesday, 09/26/2018 8:12:00 AM

Wednesday, September 26, 2018 8:12:00 AM

Post# of 459845
From today's PR.

My emphasis bold) is about claims being made here and emphasis on being public w/the best of the best. This is definitely the kind of Comm. I have been looking for.

ANAVEX®2-73 activates the Sigma-1 receptor (S1R) protein, which serves as a molecular chaperone and functional modulator involved in restoring homeostasis. S1R activation has demonstrated ability to reduce key pathophysiological signs of Alzheimer’s disease: beta amyloid, hyperphosphorylated tau, and increased inflammation. In a Phase 2a Alzheimer’s disease study, ANAVEX®2-73 has shown dose dependent improvement in exploratory endpoints of cognition (MMSE) and function (ADCS-ADL). Whole DNA Exome Sequencing (WES) and RNA expression genomic analysis of ANAVEX®2-73 Phase 2a Alzheimer’s disease patients was performed. The ANAVEX®2-73 Phase 2b/3 study design includes genomic precision medicine biomarkers identified in the ANAVEX®2-73 Phase 2a study.

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