Anavex Life Sciences Corp (AVXL)

[nidan7500]

bear77...welcome back man....this sounds important to MS patients and to relations w/BIIB? Excellent find.

Results: Sup from MS B cells were toxic to OL, those from normals were not. ACTH, DM and Anavex®2-73 all markedly inhibit OL death induced by MS B cell Sup. Antagonists of MCR or s-1R added prior to Anavex®2-73 reverse the ability to block B cell Sup mediated cytotoxicity.

Conclusions: ACTH, DM and Anavex®2-73 are able to inhibit B cell Sup mediated death of OL in vitro. Since there is progression and degeneration in many treated MS patients, development of agonists for MCR and s-1R are potential protective treatments for patients with MS.

Nicely done.