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Tuesday, 09/25/2018 5:37:22 PM

Tuesday, September 25, 2018 5:37:22 PM

Post# of 459848
The PM process as well as the outcome of this trial are(IMO) equally important. I hope we see each patient respond favorably as regards their treatment and results. That is an important numbers detail, the more the better and SP changes should correspond once everyone figures out what the results mean. We need to avoid the whole pass/fail thing as much as possible. BTW, it's gonna pass.

I hope we can avoid the old pass/fail day-long statistical discussions. The Precision Medicine process is about using the science (repeatedly)and engineering good science beginning to understand why those who did not respond as fully did what they did.

Sure, effective treatment is what we all want to see, but the science-knowledge building process is just as important. At some point, when the science has been understood, the whole placebo arm will not be done in future trials, except for the first 1 or 2 of a type/indication. The trials will be simple verification that the science predictions were correct. Like turning on a light switch. Massive trials and complex statistical analysis will all be a thing of the past.

Looking forward to trial results with large numbers of pts who responded well. Equally interested in what HH has to say about P.M. and what he and the team learned. IMO that is what future partners will pay for, the massive capability of AVXL and CNS cellular homeostasis.
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