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Re: Biobillionair post# 144479

Monday, 09/24/2018 11:02:17 PM

Monday, September 24, 2018 11:02:17 PM

Post# of 426315
I'm near certain that we'll have a very significant CV death risk reduction.

1) JT said so himself during his CNBC interview.

2) Based on other trials, there should be a minimum of 400 CV deaths in RI (in FOURIER, the ratio of PE events : CV deaths was 4 : 1, so just based on this, we should have 400, probably more due to sicker population and longer trial). I can't imagine a scenario in which CV deaths represent such a huge portion of PEs, but don't contribute heavily to the 25% composite MACE PE.

3) Even ASCEND showed 18% risk reduction with CV deaths.

No clue what risk reduction for CV deaths will be, but I'm guessing >20%, which is asinine!
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