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Re: Jonjones325 post# 166535

Monday, 09/24/2018 9:35:06 AM

Monday, September 24, 2018 9:35:06 AM

Post# of 462711

-the 19 left all fit our profile and all have Some type of benefit regardless which dosage they’re on. It’d be nice if they provide some RWE for them


I would expect about 20% having the gene variants leading to reduced response to A2-73. I would also expect some of the remaining 80% to have issues with A2-73 blood concentration.

Unlikely we have more than 5 - 6 strong responders, but perhaps assuming dosing has been optimised some time ago.

Overall I would hope we see reduced decline compared to SOC for the remaining group.
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