Anavex Life Sciences Corp (AVXL)

[sokol]

Professor Harald Hampel, MD, PhD, AXA Research Fund & Sorbonne University Excellence Chair, Department of Neurology, Sorbonne University, Paris. Speaker of the Alzheimer Precision Medicine Initiative (APMI)

"It is time for a paradigm shift towards the implementation of precision medicine using supportive pathophysiological biological markers for enhanced risk screening, detection, patient recruitment and treatment of Alzheimer's disease". "The biomarker-guided ETHERAL trial is bringing us one step closer to realizing the potential of a precision medicine and precision pharmacology approach to treating this devastating disease."

It is time for a paradigm shift - especially in the area where drugs developed under the old system for serious diseases like AD do not work. However, people are uncomfortable with anything that is new and they are resistant to change.Most people do not like change of any sort.

Bob Farrell said something that not only applies to the stock market generally to everything that goes on in life. The stock market reflects sentiments of how particpates, people, react. As Bob Farrell observed:

“Change of a long term or secular nature is usually gradual enough that it is obscured by the noise caused by short-term volatility. By the time secular trends are even acknowledged by the majority, they are generally obvious and mature. In the early stages of a new secular paradigm, therefore, most are conditioned to hear only the short-term noise they have been conditioned to respond to by the prior existing secular condition. Moreover, in a shift of secular or long term significance, the markets will be adapting to a new set of rules while most market participants will be still playing by the old rules.”

For the most part, scientists and members of the medical profession deal with what they believe is the ”known”. Anavex has moved forward into ”unknown” territory, and all of these people that are comfortable with the ”known” desire to stay where they are in that comfort zone. They are conditioned to hear only the noise they have been conditioned to by the existing secular condition. This has been true throughout history. Recall, the beliefs such as the earth is flat, the sun revolves around the earth, Semmelweis proposed practice of washing hands with chlorinated lime solutions in 1847 while working in a Vienna hospital, and many other examples met with resistance throughout history.

We will continue to hear voices of resistance, but I am convinced by years of research by members of this board that we are on the right path.

So yes, even scientists may be resistant to change, and then there is this thing about ”influence” as an article in today’s WSJ suggests.

Drugmakers’ Free Services Spur Government Scrutiny -WSJ today - Biogen in the news.

”Fed­eral pros­e­cu­tors are prob­ing whether big drug mak­ers in­clud­ing Sanofi SA, Gilead Sci­ences Inc. and Bio­gen Inc. po­ten­tially vi­o­lated laws by pro­vid­ing free ser­vices to doc­tors and pa­tients, ac­cord­ing to a Wall Street Jour­nal re­view of se­cu­ri­ties fil­ings.

Drug com­pa­nies say the ser­vices, such as nurses and re­im­burse­ment as­sistance, help doc­tors and pa­tients. But the prac­tices, which have be­come more preva­lent as drug­mak­ers have in­tro-duced more com­plex and ex­pen­sive drugs, are drawing scru­tiny over whether they serve an il­le­gal com­mercial pur­pose: in­duc­ing sales.”

With the amount of money at stake, there will always be ways invented to ”influence”.