Friday, September 14, 2018 11:15:25 AM
Fact is, Anavex Life Sciences Corp will be a revenue-generating, profitable pharmaceutical with the successful conclusion of just one of any of the three clinical trials being arranged and conducted. If any one of these proves successful — minimal or no adverse events (side effects), coupled with any sort of symptomatic stabilization or improvement — Anavex 2-73 will gain regulatory approval for medical use. Twenty-first century medicine thereafter will never be the same.
But, what are the chances of sales approval for one of the three central nervous system conditions being tested? Extremely high.
Think not? Find and present any evidence, either murine (lab rodent) or human even hinting that Anavex 2-73 fails to reconnect and restore normalized neuron functions. There is none. Quite the opposite. A multitude of murine studies show efficacy, affirming the mechanism of action of the drug, the re-connection of disconnected mitochondria with their normally-connected endoplasmic reticula. With this re-connection, facilitated by Anavex sigma-1 receptor agonists, neurons function normally. The disease state is obviated.
I make the challenge again. Find and present any laboratory or clinical evidence that the Anavex mechanism of action does not actually occur; that the company’s sigma- receptor agonists don’t really restore neurons to a pre-disease, normalized state.
Or, try to find a human with professional competence who will tell why the Anavex molecules can't work as claimed and demonstrated in murines (or humans). The silence of the matter is telling.
If the Anavex sigma- receptor agonists actually failed therapeutically, this would be easily confirmed in lab rodents with parallel or transgenic central nervous system defects equivalent to those in humans. Simply, there are no lab rat or mouse failures of Anavex 2-73 therapies when applied to appropriate CNS conditions.
The problems are not with the Anavex mechanism of action. The problems are the many regulatory and procedural complications of required to affirm safety and efficacy in humans. But with time (several years?) those will be resolved. It took over a decade for penicillin to come to market. In the modern era, it may take Anavex half a decade for its sigma-1 receptor agonists — with far greater influences on medical practice and therapies.
Recent AVXL News
- Anavex Life Sciences to Present at the H.C. Wainwright 26th Annual Global Investment Conference 2024 • GlobeNewswire Inc. • 09/03/2024 11:30:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/06/2024 09:21:05 PM
- Anavex Life Sciences Reports Fiscal 2024 Third Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 08/06/2024 11:30:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Third Quarter Financial Results on Tuesday, August 6, 2024 • GlobeNewswire Inc. • 08/01/2024 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/30/2024 09:20:53 PM
- Anavex Life Sciences Announces Translational Biomarker Data for ANAVEX®2-73 (blarcamesine) in Fragile X Syndrome (Major Cause of Autism) at the 19th NFXF International Fragile X Conference • GlobeNewswire Inc. • 07/30/2024 11:30:00 AM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 07/29/2024 09:21:49 PM
- Results from Anavex Life Sciences Landmark Phase IIb/III Trial of Blarcamesine Presented at Alzheimer's Association Conference • GlobeNewswire Inc. • 07/28/2024 09:00:00 PM
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
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