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Re: DanWebzster post# 209

Tuesday, 09/11/2018 1:17:40 PM

Tuesday, September 11, 2018 1:17:40 PM

Post# of 438
KDMN ( scientific backgrounder)

KDMN focus is on Roh Kinases. Roh Kinases are differentiated in their ability to regulate cytoskeletons.

Roh Kinases are referred to colloquially as either ROCK-1 and ROCK-2

ROCK-1 are active in cytoskeleton destruction throughout the body, but especially in liver, spleen and kidney.

ROCK-2 are active in brain and muscle development and stabilization.

KDO25 is KDMN's in-licensed ROCK Inhibitor that KDMN has made more selective to ROCK-2 inhibition. Theoretically, these changes have made this ROCK Inhibitor therapeutic against fibrotic diseases.

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