NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

Longfellow95,

Remember what Michael Platten, MD, of Heidelberg University, said of the Liau et al study? He is of the same University as Wolfgang Wick.

Article: Addition of a Personalized Vaccine to Standard Therapy in Glioblastoma.

Quote:

“At this year's ASCO annual meeting, in an Education Session on vaccine therapy for glial tumors, Michael Platten, MD, of Heidelberg University, said of the Liau et al study: "This whole tumor vaccine was well tolerated, as this is the case with almost all vaccines. The primary endpoint, which was progression-free survival, has not been reported, but the median OS of the whole intention-to-treat population was 23 months and in the MGMT methylated patient population, was 34.7 months. We cannot, based on those data, determine efficacy of this approach.
Glioma patients may harbor spontaneous immune responses to tumor-associated antigens, and vaccine trials that employ these antigens are usually restricted to a class I presented epitopes, and are usually restricted to common HLA alleles, such as HLA A2, he continued. "Tumor-associated antigen vaccines are typically given as multi-peptide vaccines. We know peripheral immune responses may be associated with increased survival, but there is no firm evidence that this is a true, very good, reliable biomarker."

And quote:

"In conclusion, Platten said: "There's no evidence for clinical efficacy for vaccine therapies from randomized clinical trials. I think we should complement expression in leukemic stem cells and MHC prediction algorithms by ligandome analysis and intratumoral T-cell analyses to select appropriate antigens."

https://www.medpagetoday.com/reading-room/asco/immunotherapy/74315?xid=nl_mpt_DHE_2018-08-03&eun=g824783d0r&pos=1&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20-%20Salary%20Survey%202018-08-03&utm_term=Daily%20Headlines%20-%20Active%20User%20-%20180%20days

https://www.klinikum.uni-heidelberg.de/Michael-Platten.124948.0.html
https://www.klinikum.uni-heidelberg.de/Wolfgang-Wick.124949.0.html