Sunday, July 29, 2018 3:32:05 PM
Not really. “Precision medicine,” accurately, is the precise connection of a thoroughly accurate genetic disease profile with treatments known to work against the diseases with whose with the particular genetic profiles. First, diagnose the disease. Then, for treatment precision, chose therapies known to work with the particular genetic profiles.
For Alzheimer’s (and other central nervous system diseases), there can be no precision medicine without treatments, drugs that will provide actual symptomatic relief.
It is not genetic profiling, “precision medicine,” that can provide a glimmer of hope for those suffering with Alzheimer’s. In fact, it’s Anavex Life Sciences Corp and Anavex 2-73 that can bring particular hope, even successful treatment.
Without precision medicine, without establishing the genetic profiles indicating Anavex 2-73 efficacy or inefficacy, Anavex 2-73 would be administered imprecisely; given to all with Alzhemier’s symptoms. With that imprecise approach, current evidence indicates the drug would be efficacious for perhaps only 80% of those treated. About 20% would have genetics that preclude efficacy.
With precision diagnosis and consequent Anavex treatment (treating only the 80% with favorable genetics), efficacy can approach 100% for those so treated.
The real significance of “precision medicine” is that it will allow the selection and treatment of only genetically-favored participants in the up-coming clinical trial in Australia. Virtually all of the 450 invited participants can be known to have Anavex-favorable genes, before the first dosage is administered. This will assure an exceptional frequency of successful treatment, thereby assuring regulatory approval for commercial sales.
Precision medicine allows Anavex to include in the new clinical trial only those who have the genetics that allow the drug to rejuvenate and restore neuron functions.
It’s the drug itself that will be the story, not the precision medicine. Precision medicine will simply allow a more facilitated approval process. It allows Anavex Life Sciences to stack the clinical deck only with Anavex aces.
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