Wednesday, July 25, 2018 10:08:29 PM
As a biologist, I’ve scrutinized any number of otherwise obscure research reports dealing with Anavex sigma-1 receptor agonists. The most revealing and indicative are the many reports of the Anavex molecules acting in murines, lab rats or mice, against a range of diseases and conditions.
Those reports, coupled with Anavex researchers laying out various molecular and cytological mechanisms of action of their sigma-1 receptor agonists, prompted me several years ago to take a position in AVXL equities. I didn’t bet my ranch; used only discretionary funds whose loss would not impact my financial status in any way. As with all continuing to maintain a strong AVXL position, I’ll either lose my investment, or, in time (a few years, at least) it will be handsomely rewarding. Here is my analysis and perspective of the most recent Anavex information, at this URL:
https://www.anavex.com/wp-content/uploads/2018/07/Anavex-AAIC-2018-DT-01-Presentation.pdf
More so than ever before, I’m convinced my investment in Anavex Life Sciences Corp was a good one. Here are my thoughts on the matter.
Could an Anavex molecule actually stop or reverse the universal progression of Alzheimer’s dementia? This was indicated by a number of murine studies. The unique abilities of the Anavex drugs (orally administered) to ably cross the blood/brain barrier and become incorporated inside neurons (nerve cells), and thereafter restore previously lost nerve functions was both demonstrated in murines, and the mechanisms of these actions were graphically described.
But all of that was only in animals. In humans? Yes, there, too; but only in a small population of Australians, in a clinical trial whose goal was merely safety and tolerability, not efficacy. Wonderful results for a significant portion of those trial participants. Safe (no disqualifying side effects), and tolerable (dosages effectively determined).
The larger question, now, is what fraction of a large, generalized Alzheimer’s population might favorably respond to Anavex 2-73 treatment. That small Phase 1 clinical trial was insufficient for this determination.
Now, plans are underway for a full-scale double-blind, well-controlled clinical trial of Anavex 2-73 against Alzheimer’s disease. I’m eager to learn how that trial turns out. But with the new information just released, it's almost certain that clinical trial will yield data allowing (well, forcing) FDA approval.
Now, Anavex has discovered genomic factors that predispose Alzheimer’s patients to favorable treatment by Anavex 2-73. Those with the disease and the favorable genes will have their Alzheimer’s symptom prevented from progressing, or have them suppressed. Either outcome exceeds any existing standard of care.
The genomic factors were anticipated; now known, and they will be used to select participants in the up-coming Phase 3 clinical trial. In effect, Anavex now gets to include only those who will favorably respond to treatment; having the pre-tested genes for such.
Wonderfully, the recent Anavex announcement indicates that about 80% of Alzheimer’s patients have Anavex-favorable genes. Until this was announced, the number of Alzheimer’s patients that could be treated was unknown. Now, it’s known — four out of five. Moreover, genetic testing can pre-select patients, so the 20% that are not open to Anavex treatment will not be unsuccessfully subjected to it.
To gain FDA approval for a new drug, it must be a) safe (few side effects), b) be efficacious, yield positive treatment outcomes, and c) equal or eclipse existing standard of care drugs.
The new information raises no safety issues. As in both murines and humans, the Anavex molecules are safe.
The big Phase 3 clinical trial will reveal significant, positive treatment outcomes for the vast majority, or universal fractions of trail participants. Anavex has everything stacked in it’s favor: include in the trial only those with treatment-favorable genes. Significant positive clinical outcomes are now assured.
Lastly, any of those treatment outcomes will eclipse the treatment outcomes of any existing Alzheimer’s drug. The standard of care is presently minimal; merely slowing for a moderate period the rate of symptomatic decline. Every shred of evidence, both murine and human, indicates Anavex 2-73 will either stop the progression of Alzheimer’s symptoms, or even reverse them. With either of those outcomes, FDA approval is mandated.
In summary, the biggest news is the determination that 80% of Alzheimer’s patients have Anavex-favorable genes. Clinical matters will progress more slowly than wished, but I have a five-year perspective on my AVXL investment. Today, I’m confident that in five years my Anavex holdings will be quite valuable, and more importantly, Alzheimer’s disease will, for at least 80% be wonderfully treatable.
Recent AVXL News
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/12/2024 09:45:00 AM
- Anavex Life Sciences to Present at the Noble Capital Markets Virtual Healthcare Equity Conference • GlobeNewswire Inc. • 04/11/2024 11:30:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/09/2024 09:45:00 AM
- Anavex Life Sciences Corporation Class Action: The Gross Law Firm Reminds Anavex Life Sciences Investors of the Pending Class Action Lawsuit with a Lead Plaintiff Deadline of May 13, 2024 - AVXL • PR Newswire (US) • 04/05/2024 09:45:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 04/02/2024 09:45:00 AM
- Lost Money on Anavex Life Sciences Corporation(AVXL)? Join Class Action Suit Seeking Recovery - Contact The Gross Law Firm • PR Newswire (US) • 03/29/2024 09:45:00 AM
- Investors who lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 03/26/2024 09:45:00 AM
- Anavex Life Sciences to Present at the 23rd Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 03/25/2024 11:30:00 AM
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