Anavex Life Sciences Corp (AVXL)

[rocalinda]

Like many of the smart science types on the board, I am extremely pleased with what the company disclosed today. What's not to like about:
- Confirmed safety & dose-dependent target engagement with SIGMAR1 using PET
- Exome sequencing showed response-linked gene variants using formal concept analyses (FCA)
- Identified SIGMAR1/COMT variants shown to be linked to limited clinical response
- Targeted therapy benefit on WT variants is expected for about 80% of patient population
- Confirmation through high SIGMAR1 RNA expression levels linked to clinical response
- Results consistent across cognition (MMSE) and activities of daily living (ADCS-ADL)
- Identified actionable genetic variants support enrichment with genetic biomarkers in the
clinical development of ANAVEX®2-73

I had no expectation of significant market reaction, up or down, thus no disappointment for me with today's price action. Actually, I see the drop to $2.65 and subsequent recovery to 3 as a bullish signal going forward. Relatively low volume attributable to momentum traders expecting a pop bailing out disappointed, and, unfortunately, some fellow retail longs also taken down by MM's scooping up stop loss positions. No material institutional participation today in my opinion.

The reaction to BIIB after hours (following presentation at AAIC) confirms what many here have pointed out as not impressive results with their/Alsai's drug.

The safety and efficacy of Anavex 2-73 continues to be verified. Meaningful, positive or negative, PPS will only come with further trial results being released or announcement of partnership consummation.

Make your own judgement and GL whichever road you travel.