NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

Tadasana,

Recent article on initiation of radiotherapy:

-Short delay in initiation of radiotherapy for patients with glioblastoma-effect of concurrent chemotherapy: a secondary analysis from the NRG Oncology/Radiation Therapy Oncology Group

Neuro-Oncology, Volume 20, Issue 7, 18 June 2018, Pages 966–974, https://doi.org/10.1093/neuonc/noy017

Conclusion:

Delaying the initiation of concurrent TMZ and radiation for the treatment of newly diagnosed GBM is not detrimental within the accepted guidelines of the 5–6 weeks postoperative period.

Quote:

“Tumors with methylation of the promoter region of MGMT (methylated MGMT) are known to have the greatest magnitude of benefit from the combined chemoradiation treatment, with an impressive 2-year survival rate of 50% for this molecularly sensitive group.”
https://academic.oup.com/neuro-oncology/article/20/7/966/4861801#117988259