Re: Pain and mitochondrial dysfunction. Mitochondrial dysfunction is associated with aging. That is one reason why it may be that AVXL 2-73 should be considered an anti-aging medication.
However, as Xena points out it, mitochondrial dysfunction may be caused by drugs. A few years ago my cardiologist prescribed a very high dosage of a statin because there is a history of heart disease on my Father’s side of my family. I developed pain in legs, and it was very unpleasant - actually it almost shut down my exercise altogether . I researched the problem with statins. Allegedly, this sort of pain caused by a statin is rare as many doctors say, but my investigation/research concluded that it is not so rare and related to damage to mitochondria in the body .
I explained my conclusion to my cardiologist, and he (although he did not agree) recommended I not take a statin for 30 days. I did that. The pain disappeared. He then put me on a different low dose statin in combination with Zetia. Actually, after doing the latter (low dose statin plus Zetia generic), my LDL level dropped much more than ever before, and the pain has not re-occurred. However, I self medicate by taking CoQ10 as my research indicated I should. Recently, I begin taking CoQ10 combined with PQQ (supposedly that combination increases mitochondria in the body), but possibly a better combination may be MitoQ for absorption, which may be a problem when merely taking CoQ10.
In any event, AVXL 2-73, according to my research, is neuroprotective and beneficial to mitochondria in cells. Mitochondria in cells is where biochemical processes of respiration and energy production occur. In other words, mitochondria are the engines that create energy to nourish and replenish the body. It may be that the body can take care of itself as long as everything functions as it should (homeostasis). Maintaining mitochondria in the body is key if you desire to continue to function and remain independent as we age. That is what I try to do, and I suppose I am older than most everyone on this board.
