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Re: jimmy_mcyoloswag post# 157836

Sunday, 07/15/2018 9:31:17 AM

Sunday, July 15, 2018 9:31:17 AM

Post# of 458494
Jimmy...

[Again, the scientific strategy behind a2-37 is rock solid!/quote]

Thanks for this link/science background article written in Jan 2015. I am Not dealing w/science detail just topics. I can see the exact terminology being repeated in recent papers in 2o18. Cannot help but reflect on how much insight has existed on the base for AVXL product science and for how long it has been known. Makes one question why this path has not been more thoroughly studied by BP/FDA/others? They chose instead to keep repeating the Amyloid hypothesis which of course was a dry hole. This is not new.

This entire area strikes me as at least unusual where so many talented people had key insights but never went past the theory level. The establishment did one massive repeated failure after another? In retrospect will the solution to the CNS disease swamp be a replay of the Fleming anti biotic model? Are we going to succeed in spite of our established system of massive trials, expense and wasted time? It looks like the basic causal-linked knowledge has been there all along.

What will we learn form a discovery process standpoint? Is that why BIIB and maybe others are in denial? Are they afraid of the big collective AHHHAA moment we are hopefully about to experience? I guess we'll see soon enough.

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