Anavex Life Sciences Corp (AVXL)

[sokol]

Nidan:

This is what I sent a few days ago to:

Alzheimer's Association Public Relations Department
Phone: [phone]
Email: [e-mail]

Apparently, Biogen and Eisai plan to provide late breaking news at your conference about BAN240. So far, their disclosures have been sketchy.

The Biogen and Eisai drug, BAN240, failed before. So what's new about their latest announcement?

WSJ article: ”An­a­lysts said questions re­main about the re­sults of the BAN2401 study. For one thing, researchers used a novel mea­sure of ef­fi­cacy that was de­vel­oped by Ei­sai’s in-house re­searchers, rather than stan­dard mea­sures in the field.”

They, Biogen and Eisai, obtained a different outcome with a new measure of efficacy. Biogen’s partner Eisai, a Japanese pharmaceutical company, came up with a new standard to measure ”success”. This ”success” measured by a new internally conflicted standard should by itself raise a red flag.

Even then this ”success” may not be so great considering their drug is an infusion and the same WSJ article points out: ”The study in­volved 856 sub­jects in the early stage of the dis­ease. Among the side ef­fects that the com­pa­nies reported were re­ac­tions at the sites of the in­fu­sion and swelling around blood ves­sels ob­served with brain imag­ing.”

Making multiple trips to a clinic or medical office for infusions as opposed to taking a pill poses difficulties in addition to the risks of adverse events, and for what: BAN240 does not stop or reverse Alzheimer’s. To sum up : The drug is IV injected, only works at the highest dosage if at all, takes months to kick in, and the new cognitive tests were created in house. It would be of interest to know what percentage of those receiving ONLY the highest dosage, the one that reportedly works, developed adverse events.

This very recent announcement is lacking many significant details even though Biogen/Eisai have been conducting research and clinical trials on the drug for a very long time.

Alzheimer’s is a cruel disease. Let's not promote false hopes - especially one based on the amyloid hypothesis that has been virtually a 100% failure. What does the AAIC know about this late breaking news about BAN24 that was a once-failed treatment for Alzheimer’s disease?

I and many others that have friends and families affected by Alzheimer’s deserve to know the plain and simple truth as opposed to the promotion of more of the same that may not work!