Thursday, June 14, 2018 5:12:24 AM
"A sham or placebo treatment for the control group was considered neither practical (patients would be able to sense heat when they were receiving TTFields [tumor-treating fields]) nor appropriate (due to the burden for patients and caregivers and the need to shave the scalp and have the transducer arrays placed)," the study investigators argued when the interim data were published.
According to Dr Stupp, this is an unfair criticism. Neither prior or current radiotherapy trials nor trials of temozolomide and many other chemotherapy drugs were placebo controlled, he explained. "Some of my own colleagues are conducting new trials without a placebo control, as they consider it too burdensome and unethical for the patients," he added.
......When speaking about dcvax in recents medscape article ..... Stupp and Fine expressed concern with the study design. With a crossover allowed at progression, approximately 90% of patients received the vaccine, and so they suggested that it would be difficult to tease out any benefit that the patients may get from the vaccine
STUPP IS CONCERNED WHEN HE IS NOT GETTING PAID. Sickening to me.
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