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Re: poguemahone post# 152545

Sunday, 06/10/2018 9:35:01 PM

Sunday, June 10, 2018 9:35:01 PM

Post# of 458304
How Many Might Anavex Treat?

Good question. What percent of those with Alzheimer’s might Anavex 2-73 effectively and efficiently treat? Presently, unknown, of course.

For a start, presently, the question is, what percent of the Alzheimer’s people in the upcoming clinical trial will be effectively treated? How many will benefit? With the ability to carefully select for the trail only those with Anavex-favorable Alzheimer’s genetics, efficacy rates in the trial should be very high, if not just downright remarkable. With trial results approaching any of that, FDA approval of the drug should be coming forthwith.

Will that mean, then, that Anavex 2-73 will work on only a small fraction of Alzheimer’s patients? If it’s for only 10% with the disease, Anavex Life Sciences Corp will be a success (and our AVXL share prices will be rewarding).

But there is good reason that the drug will help with the successful treatment of a diversity of CNS diseases — including, at least to a degree, Alzheimer’s cases lacking a strong genetic component. Why? Because in all cases the mitochondrial dysfunction I described in a previous post causes the problems. At least to a degree, if not altogether markedly, our drug restores cellular function (“homeostasis”).

Now, for people with advanced cases, where nerve function is significantly disrupted, after several years of debility, the drug may not be able to put things back together. At some point, Alzheimer’s may have incurred permanent, irreparable nerve damage.

But what hasn’t been yet tested or known is the prophylactic abilities of Anavex 2-73, the ability of the administered drug to prevent or reverse the onset of Alzheimer’s and other degenerative CNS diseases. Because of the drug’s unique and powerful mechanism of action, there is every reason to believe it will have profound prophylactic capabilities. Aunt Matilda might be prescribed the drug at the very first sign of memory deficiency. “Doc, I’m forgetting where I left my keys in the house.” “Well then, here, get this prescription filled. Your insurance company will be relieved. In a few weeks, you’ll be remembering all sorts of things. This new Anavex drug is really remarkable.”

Good chance that the biggest, most effective use of Anavex 2-73 will be to prevent or treat the early onset of CNS diseases. Giant global market for such.

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