NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

jon_k84,

Welcome and congratulations on a well thought out post. I just want to reaffirm Longfellow's assessment of Linda Powers motivation which is legacy not money. She has made money along the way and this has given her the option to finance NWBO when shares were cheap to pick up which helps her maintain control of this company. The sale was set up to go to friendlies and was done at a time when NWBO itself was at an apparently vulnerable point. NWBO will be a case study in how to take a development stage biotech with game changing science through the gauntlet and "to the house".

As for Direct, there will not be any long term use of this product in my opinion. The mouse models saw complete clearing of tumors in 4 weeks. With improvements made to Direct since Phase 1 was completed and several key changes to the treatment schedule and desirable dosing as well as expected adjuvent use and multiple tumors injected, results should be seen in 8 weeks or less. Longer term followup will be done but I believe Right To Try and a model potentially being developed for use in immunotherapy trials will set the stage for early proof of efficacy in the next Direct trial. Best wishes.