Monday, May 21, 2018 6:41:57 PM
It is reassuring to have people like yourself, Talon, Xena, Investor and many others here, not just to agree but to reason and generally learn/add value. The scope of AD trial evaluation WW is of course massive. Keeping it as an example for CNS disease treatment and causal analysis discussion for the last decade one can see how the business vs medicine you describe above is totally valid. The polarized silo discussions here over the past year repeatedly make this point well .
So now what? When precision medicine trials are done (as I get this) they will test and measure patient specific (some word-markers) which either will or will not respond as predicted. Some patients will/may respond while others will, to some degree or not. This is not a tough concept to appreciate which should certainly lead some place, the next level of knowledge. It is a learning process we all recognize. And, when some patients respond while others do not then the next step is to analyze what is (define how here) different between the patients and define why that is true.(as Talon would say-we must have the same number of takeoffs and landings) The really good news is anyone who has ever used AI tools will tell you that you better have your shat in one pile else the model will just not work. Therefore, learning must be a compulsory output from precision medicine-trials, data gathering as compared to using weak models of short term memory or cognition to decide if you are on the right track. We will have hard data to build on.
This is going to work eventually. My thinking is Dr.M. will define the patients base well enough to ensure a positive outcome, maybe not everyone but many/most will present improved quality of life. This same process may be applied to any CNS indication. I also pray a lot, I learned how to do that when I was in the service.
All the best.
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