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Friday, May 11, 2018 1:39:36 PM
From your linked article...
With his colleagues Giovanna Rappocciolo and Charles Rinaldo, Mailliard found that HIV and other viruses can exploit these TNTs to spread among dendritic cells. Inhibition of the TNTs appears to inhibit the spread of HIV, Mailliard said. Furthermore, the researchers found that those extremely rare people infected with HIV who are able to control the virus without any antiretroviral therapy (so-called “long-term nonprogressors”) have a defect in their dendritic cells’ ability to form TNTs. This appears to be a genetic trait related to their cellular cholesterol levels. Now the researchers are investigating whether drugs that are commonly used to lower cholesterol levels could be repurposed to control viral infections by limiting reticulation.
HIV isn’t the only infection that takes advantage of the dendritic cells’ ability to form TNTs.
Apparently, quite a few cells do...
Many cell types appear endowed with the capacity to form TNTs with one another.
...
Cells of the immune system, notably macrophages, dendritic cells (DCs), NK, and B cells, extensively use TNTs to communicate [6, 21–27]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474251/
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