Anavex Life Sciences Corp (AVXL)

[nidan7500]

Thanks Doc for your assessment of these slides. We will need your continuing informed and rational thoughts over the next couple of months. Incomplete or poorly done work serves no one well. Please set the bar along with other qualified posters. The army of unqualified whiners and complainers will be ignored as usual.

By this time next week we will have seen/heard the AVXL..." what's next". The scope and level of detail provided will probably set the bar for the rest of the year at AVXL. We need M. to be detailed and global on RETT trial work (exactly-who/what/when/how/how much)?? Anything less just will not work, IMO. Ambiguity, Smoke and BS will be a big disappointment at this stage.

Based on other information, I am expecting much more detailed information on what has been learned about AUS AD markers. I expect a more restricted Precision protocol trial scope(who) will be treated based on AUS/other findings. We should also hear more about AD trial planning collaboration and any ongoing FDA role with RWE.

We expect M. to provide a strong report. The detail level and the scope of his talk will be picked apart of course, as he should expect that comes with the turf. He needs to present a scientifically powerful report and he needs to do that with thoughtfully intense leadership skill.

This is not about drama it is about recognizing patient lives along notwithstanding the current leadership vacuum at the FDA and BP WW on CNS. Lead, follow or get out of the way. As precision increases we should expect more focus on patients, what is happening with them and how can the learning process benefit those excluded from the currently treated pool. This whole process should be about getting real and not some abstract(SO WHAT) scientific exercise. Like we have said, if you want/expect to be in the room, ACT LIKE IT.