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PDF]Involvement of the sigma1 (r1) receptor in the anti-amnesic, but not ...
anavex.com/files/BJP.pdf
by J Espallergues - ?2007 - ?Cited by 27 - ?Related articles
Key results: In vitro, ANAVEX1-41 was a potent muscarinic (M1>M3, M4>M2 with Ki ranging from 18 to 114 nM) and selective s1 ligand (s1, Ki ¼ 44 nM; s2, Ki ¼ 4 µM). In mice, ANAVEX1-41 failed to affect learning when injected alone (0.03–. 1 mg kg?1), but attenuated scopolamine-induced amnesia with a bell-shaped ...

Anti-amnesic and neuroprotective potentials of aminotetrahydrofuran ...
anavex.com/files/ICAD_2008_Abstract_Anavex.pdf
affinity for M1, M2, M4 muscarinic acetylcholine receptors and s1 protein. Both compounds are potent anti-amnesic drugs alleviating learning impairments observed in mice after the central (i.c.v.) injection of amyloid ß25-35 peptide (Aß25-35). Central administration of Aß25-. 35 induces within one week histological and ...

p2.216 anti-amnestic and neuroprotective activities of anavex2-73
anavex.com/files/ICAD%202009%20POSTER%20216.pdf
Contact [e-mail]. Background: Tetrahydro-N,N-Mmethyl-2,2diphenyl -furanmethanamine (ANAVEX2-73) is a new sigma-. 1 receptor (SIR) ligand, with a sur-micro-molar affinity (IC50= 860 Nm & Xc Ki= 710 nm) and low affinities (IC50=3.3-5.2µM) for M I -M4 muscarinic receptors. No affinity was found for sigma-2.

[PDF]Blockade of Tau Hyperphosphorylation and A&beta - Anavex Life ...
www.anavex.com/my_uploads/Blockade-of-Tau-Hyperphosphorylation-and.pdf
by V Lahmy - ?2013 - ?Cited by 62 - ?Related articles
Apr 3, 2013 - hydrochloride (ANAVEX2-73) presents such a mixed s1/muscarinic receptor profile, with a moderate affinity range. Indeed, the compound has a sub-micromolar affinity for the s1 receptor (IC50 ¼ 0.86 µM) and micromolar affini- ties for muscarinic human recombinant M1—M4 receptors. (IC50 ¼ 3.3–5.2µM), ...

Inserm - Anavex Life Sciences
anavex.com/files/Maurice_Poster_Montpellier_May_2007.pdf
behavioral effects of ANAVEX2-73 particularly at the 1000 µg/kg dose of compound. Both ANAVEX1-41 and ANAVEX2-73 are thus promising neuroprotective compounds in this AD animal model. The mechanism of the combined activity at. M1/M2/M4 muscarinic receptors and s1 receptors must be investigated further.

Antiamnesic and Neuroprotective Effects of the ... - Semantic Scholar
anavex.com/files/Neuropsychopharmacology%202008.pdf#13
by V Villard - ?2008 - ?Cited by 73 - ?Related articles
ANAVEX1-41 is a new aminotetrahydrofuran derivative. (Vamvakides, 2002; Espallergues et al, 2007) acting as a s1 protein activator, with a high affinity (44 nM) and selectivity. The CEREP profile of the compound showed that it also presents nanomolar affinities (18–114nM) for muscarinic receptors (M1>M3, M4>M2), ...

[PDF]1207 AAIC Tangui Poster - Anavex Life Sciences
www.anavex.com/my_uploads/Neuroprotective-efficacy-of-Anavex-2-73.pdf
by T Maurice
muscarinic M1—M4 receptors (IC50 = 3.3 - 5.2 µ?), sodium channel site 2 (IC50 = 5.1 µM), and. NMDA receptors (IC50 = 8.0 µ?). ?. We showed the neuroprotective potential of ANAVEX2-73 against amyloid toxicity in mice. In particular, ANAVEX2-73 attenuated the oxidative stress, caspases induction, cellular loss and ...