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Re: frrol post# 221129

Thursday, 03/15/2018 1:47:06 PM

Thursday, March 15, 2018 1:47:06 PM

Post# of 402819
ffrol, I did some tinkering with Galera's GC4419 phase I results and got a group of 19 subjects with dose at least 90 mg and treatment duration at least 5 weeks. I counted only SOM cases that occured before the end of treatment period. The group should be reasonably comparable to IPIX SOM trial.

Funnily enough - comparison with brilacidin SOM trial tells that B slightly outperforms GC4419 both in incidence rate and in delaying the onset. Add to that the fact that in GC4419 trial antifungals were allowed, which is rather strange because they clearly are confounding factor. Currently I have no way of knowing if this is the case also in GALERA p2/3 trial. And, of course, I don't know if antifungals were allowed in IPIX trial. I hope not.

Awyway, not bad for an oral rinse.
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