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Re: dabullishbear post# 16910

Thursday, 03/08/2018 4:35:51 PM

Thursday, March 08, 2018 4:35:51 PM

Post# of 21373
Prolanta inventor also invented Somavert!!!

Wen Chen (Prolanta Inventor) also invented Somavert which is known as G120R. Somavert was successfully brought through trials obtaining FDA approval and is now sold on the market by Pfizer. Somavert (G120R) is a growth hormone receptor antagonist. This drug was able to successfully inhibit growth hormone receptors to help patients who have growth hormone disorders.

Prolanta also known as G129R is Wen Chens other invention. He developed both G120R and G129R around the same time period using the exact same amino acid substitution method. These drugs are almost identical to each other.

The other interesting fact is that the structure of prolactin is similar to that of the structure of growth hormone.

Here's an article that contains information regarding the similarities of prolactin hormone and growth hormone:

https://link.springer.com/chapter/10.1007%2F978-1-4757-3600-7_7

So here you have 2 near identical drugs that are antagonists to 2 structurally similar pituiatry hormones. Antagonizing human prolactin may be effective in treating cancer because of its role in the presence and growth of cancerous tumors. The other issue with human prolactin hormone is that it is a major factor in humans becoming resistant to chemotherapy. If you can antagonize the human prolactin receptors, you can at the very least increase the efficacy of chemotherapy, which in and of itself would be a major breakthrough.

So knowing that we have 2 almost identical drugs working to antagonize structurally similar hormones, we can hypothesize that both would be almost similarly efficacious. One drug, Somavert, has already achieved FDA approval, and the other drug, Prolanta, has a strong probability to follow suit.

G129R is almost equal to G120R

IMO

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