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Re: mrmainstreet post# 121398

Wednesday, 01/24/2018 2:52:27 PM

Wednesday, January 24, 2018 2:52:27 PM

Post# of 426389
Given that the RRR projections I posted indicate the primary MACE outcome will meet 15% RRR under the most likely placebo rate scenarios, seems that the continuation was driven by a desire to get more events (and significance) on key secondaries (as JL and others have stated). Whether the DMC would go against their instructions and recommend stopping the trial for futility if that were the case would be total speculation. My guess would be they would though if warranted.
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