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Re: nidan7500 post# 137416

Tuesday, 01/16/2018 9:32:59 AM

Tuesday, January 16, 2018 9:32:59 AM

Post# of 459453
Yes, the drug is safe. The science seems definite about it acting on sodium and calcium channels, and it may also be an effective anti-amnesic, anti-depressant, and neuroprotective drug. Sigma-1 receptorsfunctionally downregulate certain proteins that play a major role in various pathophysiological conditions including depression, anxiety,epilepsy and brain injury following ischaemic stroke; it has been shown that activating the sigma-1 receptor with agonists can potentiallyreduce the impact of tau dysfunction....."

All of the above conditions may be related to the central nervous system. Blood pressure is related to the sympathetic nervous system, which is why one should check their blood pressure in the morning upon arising. Therefore, the criticism some have displayed about AVXL as if it is falsely touted as another "snake oil" is unjustified. Many diseases are related to the CNS.

Anavex has many options for obtaining FDA approval and foreign approval of AVXL 2-73 to treat various CNS and CNS related diseases. The odds of it gaining these approvals are increasing, but this is not yet reflected in the share price.

I like this from your post about new FDA rules: "Advance the use of new drug development tools and mobile technology for better capturing clinical trial data and the measurement of safety and benefit in pre- and post-market settings."

AVXL seems to be a candidate for conditional post-market approval. The technology exists to monitor it.
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