Innovation Pharmaceuticals Inc (IPIX)

[LilyGDog]

IPIX is amazing... Great post and thanks for taking the time to do this.

Well, Infinity, actually they did tell us something.

I just takes an effort to lift ones mental ass off from the whiny chair and do something called estimating. Lemme show you how:

We know that there were 6 subjects (0.462 * 13 = 6) in prurisol 200 mg group with IGA 3 that had 2 point drop. Numbers for 200 mg ITT group were 28 subjects and 18 of them were IGA 3. Let's be stingy and assume that the seventh 2 point drop in ITT did not happen in IGA 3 group. We get:

prurisol 200 mg ITT IGA 3 - 2 point change percentage: 100*6 /18 = 33.3 % (at least)

Placebo group had ITT of 30 out which 23 was IGA 3. This group had 4 subjects with 2 point IGA drop. Let's be generous and assume that all four happened in IGA 3 subjects. That means

placebo ITT IGA 3 - 2 point change percentage: 100*4/23 = 17.4 % (at most)

Risk ratio associated with 2 point drop in IGA 3 groups: 0.52 for prurisol (and probably better). A number that is known to imply clear statistical significance in 100+ subjects trials.

BTW:In Esteem 2 trial Otezla scored PASI 75 percentage of 28.8 % when calculated using LOCF. Prurisols results in p2a are probably better than that. Strange: It looks like Leo did not lie, but famous Adam F. might have. Who would have thunk THAT!