Friday, December 15, 2017 9:47:41 PM
As two of the four trials failed their primary endpoints, what you now see with the new guidances might be an effort to at least rehabilitate ICT-107's phase ii trial, so that if DCVax-L also works out, there will be three coverages.
However, it could be DCVax-L is more of an overall player than originally thought, so it's possible they needed to see if it would even be worth rehabilitating ICT-107's phase II trial. The guidances may be your answer that ICT-107 might, and I said might, under this theory, at least hold its own in the narrow hla a2+ subgroup, remember just 6 antigens used, and be at least another alternative to L, if not a first line in the narrow hla-a2+ subgroup -- wherein DCVax-L would likely have mesenchymal and at least part of classical covered.
Anyway. I kind of wrote the whole notion off for ict-107, even though I got up on my soap-box for ICT-107 to be approved already, based upon the prior phase ii trial for its subgroup, every once in a while, but now, it actually appears feasible with the new guidances.
jmho.
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