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Re: LGL8054 post# 127596

Tuesday, 10/31/2017 7:01:28 PM

Tuesday, October 31, 2017 7:01:28 PM

Post# of 474400
The additional data reveals that ANAVEX2-73 not only seems to have a wide dose-response profile but also activates neuroplasticity mechanisms and exerts noticeable neurorestorative effects on striatal dopamine axon fibers. This was confirmed by expression of a marker of axonal regeneration in the striatum, Growth Associated Protein 43 (GAP43), being co-localized with TH, which was only found in the ANAVEX2-73-treated animal cohorts but not in the control cohort.

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